Expression of interleukin 8 (IL-8) and substance P in human chronic pancreatitis

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Expression of interleukin 8 (IL-8) and substance P in human chronic pancreatitis.

BACKGROUND Changes in substance P content and a relationship between the degree of perineural inflammation and pain has been demonstrated in chronic pancreatitis. Whether a relationship exists between neural alteration and pancreatic inflammation (neurogenic inflammation) is not known. AIMS In the present study we evaluated gene expression of preprotachykinin A (PPT-A), the gene encoding subs...

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Expression of interleukin-8 in human obstructive pancreatitis.

CONTEXT Obstructive pancreatitis is a specific form of pancreatitis, which is caused by the obstruction of the main pancreatic duct due to tumors or some other causes. Interleukin-8 is induced in acute pancreatitis, but its expression in obstructive pancreatitis has not been clarified. OBJECTIVE We attempted to provide some insight into the significance of interleukin -8 in the pathogenesis o...

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Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases.

Interaction of the neuropeptide substance P (SP) and its neurokinin-1 receptor (NK-1R) plays an important role in the pathophysiology of intestinal inflammation. SP is known to stimulate production of interleukin (IL)-6 and IL-8 in the U-373-MG human astrocytoma cell line via activation of p38 MAPK (mitogen-activated protein kinase) and nuclear factor (NF)-kappaB, respectively. However, the sig...

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Cytokine gene expression in B-cell chronic lymphocytic leukemia: evidence of constitutive interleukin-8 (IL-8) mRNA expression and secretion of biologically active IL-8 protein.

To extent our knowledge on the cytokines possibly involved in the pathophysiology of B-cell chronic lymphocytic leukemia (B-CLL), the mRNA expression of a panel of 10 cytokines was investigated on purified B-CLL cells using a reverse-transcriptase polymerase chain reaction method. Whereas negative RT-PCR signals were recorded for interleukin-1 alpha (IL-1 alpha), IL-2, IL-3, IL-4, IL-5, IL-7, t...

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To extend our knowledge on the cytokines possibly involved in the pathophysiology of B-cell chronic lymphocytic leukemia (B-CLL), the mRNA expression of a panel of 10 cytokines was investigated on purified B-CLL cells using a reversetranscriptase polymerase chain reaction method. Whereas negative RT-PCR signals were recorded for interleukin-la (IL-la), IL-2, IL-3, IL-4, 11-5, IL-7, tumor necros...

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ژورنال

عنوان ژورنال: Gut

سال: 2000

ISSN: 0017-5749

DOI: 10.1136/gut.47.3.423